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3×4 Genetics Review: Helping Health Practitioners Provide Better Care?

Written by Samantha Odake, BS | Last updated:

Overview

  1. Products: Genetic testing service that provides pathway-based wellness reports and works with practitioners.
  2. Cost: $299 per test.
  3. Reports: Covers topics such as diet, exercise, stress, detoxification, inflammation, and nutrient needs.
  4. Raw data access: No clear option for downloading complete raw genetic data.
  5. Privacy: 3×4 Genetics claims not to share or sell user data.
  6. Alternatives: Advanced platforms like PromicsEdge offer polygenic risk scoring, multi-omics integration, broader reporting, and published scientific validation.

3×4 Genetics Pros and Cons

Pros

  • Practitioner support and educational content for functional medicine providers
  • Covers a range of general wellness categories such as brain health, cellular health, and nutrient metabolism

Cons

  • Relies on a small SNP panel with no polygenic risk scoring (PRS), limiting predictive power
  • Recommendations are broad and generic, often applicable to anyone regardless of genetics
  • No integration with lab results, symptoms, or other health data (no multi-omics)
  • No published, peer-reviewed validation studies to confirm accuracy or clinical relevance
  • Cannot provide ancestry-adjusted or deeply personalized health predictions
  • Very few verified third-party user reviews; mixed customer feedback
  • Missing advanced analytics and AI-driven modeling found in leading precision health platforms

About 3×4 Genetics

Founded in 2018 and headquartered in Seattle, Washington, 3X4 Genetics is a digital health company focused on using genomics to provide personalized recommendations for health, nutrition, fitness, and lifestyle. The company was founded by Dr. Yael Joffe, who serves as Chief Science Officer.

Review of 3×4 Genetics Products & Services

3X4 Genetics positions itself as a “functional genetics” company, offering genetic testing and lifestyle recommendations aimed primarily at improving health and sports performance.

Their product focuses on analyzing specific single-nucleotide polymorphisms (SNPs) across a set of health categories, including cellular health, brain health, heart and vascular health, weight, hormone balance, blood sugar regulation, musculoskeletal function, sensitivities, and nutrient metabolism.

While the branding emphasizes personalization, the underlying methodology is limited. 3X4 Genetics appears to analyze a relatively small number of SNPs compared to modern polygenic approaches, where millions of variants are assessed to provide more accurate and predictive results. Since most individual SNPs contribute less than 1% to overall disease or trait risk, this narrow scope significantly limits the test’s ability to provide validated, predictive insights.

The company’s reports group gene variants into “pathways” and offer basic, general lifestyle suggestions such as increasing certain food groups or focusing on specific exercise types. These recommendations are not deeply personalized to the individual’s unique genetic architecture and often read as general wellness advice that could apply to nearly anyone, regardless of genetic profile.

There is no evidence of polygenic risk scoring (PRS), multi-omics integration, or large-scale validation studies to confirm predictive accuracy.

3X4 Genetics does include practitioner support and education as part of its offering, which may appeal to functional medicine providers who prefer to interpret genetic data themselves.

However, the lack of advanced analytics, predictive algorithms, or integration with other health data like lab results or symptoms makes the platform less competitive for those seeking a complete, science-backed precision health solution.

Review of 3X4 Genetics Sample Report

The 3X4 Genetics “Blueprint” report is visually well-designed, with clear color-coding, infographics, and summaries that make it easy to read. However, beneath the polished presentation, the scientific and analytical depth is limited.

The report organizes genetic results into nine categories, such as cellular health, brain health, heart & vascular health, and nutrient metabolism, and further groups genes into “pathways.”

A key limitation is that the test appears to rely on a relatively small SNP panel without polygenic risk scoring (PRS) or any form of large-scale statistical modeling. This means that the results are descriptive rather than predictive: they indicate the presence of certain genetic variants but do not provide an evidence-based estimate of the individual’s risk for a condition or trait.

There is also no integration of additional health data (labs, lifestyle, or symptoms) to refine or prioritize these recommendations.

Some pathways link out to short “science” blurbs, but these lack citation of peer-reviewed validation studies showing that the reported variants have a meaningful, clinically relevant effect. Without such references, the connection between the genetic findings and the recommendations remains more theoretical than proven.

Overall, while the 3X4 Genetics sample report is user-friendly and practitioner-oriented in its layout, it functions more like an introductory genetics education tool than a clinically actionable precision health resource. In contrast, advanced genomics platforms leverage millions of variants, validated algorithms, and multi-omics data to produce recommendations that are both predictive and tailored to the individual, a level of depth not reflected in this sample report.

Note: For the most up-to-date information on 3×4 Genetics’ products, pricing, and services, please visit their official website or consult a licensed healthcare practitioner.

Health Recommendations from 3×4 Genetics

3X4 Genetics provides lifestyle, nutrition, and supplement tips linked to each genetic “pathway” in the report. While the guidance is easy to read and generally sound, it tends to be broad and could apply to most people, regardless of genetics.

Recommendations are based on a limited set of variants without polygenic risk scoring or integration of other health data, which limits their precision. There is also no clear prioritization, making it harder for users to know which actions would have the greatest impact.

Overall, the advice serves more as general education than a truly personalized action plan, lacking the predictive accuracy and tailored specificity seen in more advanced precision health platforms.

Cost of 3×4 Genetics

3X4 Genetics is priced at $299 per test, which includes the genetic testing kit, analysis, and a “Blueprint” report.

3×4 Genetics Accuracy

3X4 Genetics relies on analyzing a relatively small set of single-nucleotide polymorphisms (SNPs) and does not use polygenic risk scoring (PRS), the current gold standard for predicting complex traits and conditions. Without PRS, the reports cannot account for the combined effects of thousands of variants, meaning results are descriptive rather than predictive.

There is also no integration of other health data, such as lab results, medical history, or lifestyle factors, limiting the ability to contextualize genetic findings or produce more accurate, actionable insights.

In addition, no published peer-reviewed validation studies are available to demonstrate the scientific accuracy, reproducibility, or clinical relevance of their analysis methods. Without transparent methodology or performance data, it’s unclear how reliable the results are in guiding health decisions.

Overall, 3X4 Genetics’ approach lacks the depth, data integration, and scientific validation necessary to compete with more advanced precision health platforms.

SNP vs PRS vs Advanced PRS

To understand the limitations of 3X4 Genetics’ accuracy, it’s important to look at the evolution of genetic prediction methods.

Early genetic testing in the 2000s relied on single-nucleotide polymorphisms (SNPs), where one variant was linked to a trait or condition. While this approach was easy to implement, it proved to have little predictive value. A single SNP typically explains less than 1% of the risk for complex conditions such as diabetes, obesity, or heart disease. In many cases, single-SNP analysis is no more accurate than a coin flip.

The next step forward was polygenic risk scoring (PRS), where hundreds or thousands of SNPs are combined to provide a risk estimate. PRS offers significantly better predictive accuracy because it reflects the additive effects of many variants working together. This approach has become the modern gold standard in genomics and has been widely validated in peer-reviewed studies for conditions ranging from cardiovascular disease to Alzheimer’s.

Building on PRS, some platforms now use advanced PRS methods that integrate AI, ancestry adjustment, and multi-omics data (such as lab results, symptoms, and lifestyle factors). These approaches deliver even higher accuracy by accounting for genetic background and environmental influences, ensuring predictions are more personalized and clinically relevant. Companies like PromicsEdge apply this advanced methodology and publish their validation studies in top-tier journals, demonstrating robust accuracy. Read more here.

In contrast, 3X4 Genetics continues to rely on a small SNP panel without polygenic modeling. With no published validation studies to demonstrate predictive power, the reports remain descriptive rather than predictive, offering limited clinical or practical value compared to platforms using validated PRS.

3×4 Genetics Privacy & Security

3X4 Genetics provides only limited public information about how it handles and protects customer genetic data. While a basic privacy policy exists, it lacks clear details on encryption standards, data storage practices, anonymization methods, or retention timelines.

3×4 Genetics Reviews

3X4 Genetics has almost no reviews on third-party websites, making it difficult to verify user experiences independently. The few reviews that exist show a mix of feedback, but several limitations stand out.

Some users found the platform educational and appreciated the website and social media content for learning about genetics. However, others expressed disappointment with the depth and personalization of the reports.

Features advertised, such as insights into hormones, cold plunge responses, and other health traits, were reportedly missing from actual results. Many findings, like “tendency to diabetes” or “high cholesterol,” were described as generic and not aligned with the user’s actual genetics or lab data.

Customer support has also been criticized for being slow or unresponsive, leaving users without clarification on missing or unclear results.

Overall, while the reports are visually appealing and beginner-friendly, the limited genetic analysis, lack of predictive insights, and generic recommendations make 3X4 Genetics less suitable for those seeking actionable, personalized health guidance.

Alternatives to 3×4 Genetics

For those seeking more than broad lifestyle tips and basic genetic education, PromicsEdge offers one of the most advanced precision health solutions available today.

Compared to 3X4 Genetics’ small SNP panel and general recommendations, PromicsEdge combines cutting-edge analytics, validated science, and multi-omics integration to produce insights that are both predictive and actionable.

Key advantages of PromicsEdge include:

  • Industry-leading accuracy: Uses ancestry-adjusted polygenic risk scoring (PRS), which is the gold standard for predicting complex traits and conditions, with methods published in a Nature journal. Delivers the most accurate predictions in the industry.
  • Advanced recommendations: Goes far beyond generic wellness advice by incorporating symptoms, existing conditions, lab results, and millions of genetic variants into each recommendation.
  • Published validation: Backed by 6 published studies in top-tier scientific journals.
  • Massive data coverage: Analyzes over 200 million genetic variants, with millions actively included in each report using advanced AI.
  • Comprehensive reporting: Produces over 1,500 reports covering a wide range of health categories, from disease risk to nutrient needs and fitness optimization.
  • Multi-omics integration: Can analyze blood tests alongside genetic data to create integrated, evidence-based recommendations.
  • Strict privacy & security: Fully HIPAA and GDPR compliant, with rigorous data protection protocols.

With its unmatched data depth, scientific validation, and breadth of reports, PromicsEdge delivers a level of personalization and predictive power far beyond what 3X4 Genetics can offer. View a sample report from PromicsEdge and 3×4 Genetics to compare.

Feature 3×4 Genetics PromicsEdge
Genetic Analysis Method Small SNP panel, no polygenic risk scoring (PRS) Ancestry-adjusted PRS using 200M+ variants, millions analyzed per report
Predictive Accuracy Descriptive results only, no predictive scoring Most accurate predictions in the industry, methods published in a Nature Journal
Data Sources Used Genetics only Multi-omics: Genetics + blood tests + symptoms + conditions
Recommendations Broad, generic lifestyle tips Advanced, highly personalized recommendations based on genetics, labs, and clinical data
Scientific Validation No published validation studies 6 published studies in top-tier scientific journals
Number of Reports Limited categories 1,500+ reports across all major health areas
Integration with Lab Data None Full integration with blood tests and other biomarkers

3×4 Genetics Review Summary

3X4 Genetics offers an attractive, beginner-friendly introduction to genetics, with visually appealing reports and practitioner support. However, its approach relies on a small SNP panel without polygenic risk scoring, lacks integration with lab or clinical data, and has no published validation studies to confirm predictive accuracy.

Recommendations tend to be broad and generic, often applicable to the general population rather than tailored to an individual’s unique genetic and health profile.

In contrast, PromicsEdge delivers a clinically robust precision health platform. It uses ancestry-adjusted polygenic risk scoring on over 200 million variants, integrates genetics with blood tests, symptoms, and conditions, and produces over 1,500 in-depth reports.

Backed by six published studies in top-tier journals and compliant with HIPAA and GDPR standards, PromicsEdge offers the industry’s most accurate predictions and truly personalized recommendations.

About the Author

Samantha Odake

Samantha Odake

BS
Samantha is an engineer turned writer with a passion for helping people.

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