Full Genomes Review: Is Whole Genome Sequencing Worth the Cost?

Overview

1. Products: WGS and Y chromosome Sequencing and Analysis
2. Cost: $15 – $2900
3. Reports: Sequencing lab analysis and Full Genomes Analysis
4. Raw data access: Yes
5. Privacy: Full Genomes gives its customers full control over their data.
6. Alternatives: SelfDecode – The best option for health-focused DNA analysis with personalized reports, symptom analysis, and health recommendations.

Pros

• Extensive library for Y-Chromosome SNPs
• Full access to raw DNA data provided
• Reviews suggest good customer support

Cons

• Results can be complicated to understand
• Customers are responsible for paying for shipping both ways
• WGS is still very expensive considering its limited benefits
• No personalized health recommendations
• Does not integrate lab results
• Does not offer advanced polygenic risk scoring

About Full Genomes

Full Genomes is a DNA testing company that specializes in full genetic mapping to provide individuals with detailed information about their ancestry and health. The Full Genomes corporation is headquartered in Rockville, Maryland, USA, and was founded in 2012 by CEO Justin Loe, Paul Conroy, Leon Kull, and Abdullah Marafi.

Full Genomes was the first company to offer whole genome sequencing without a doctor’s order in January 2015. 

Review of Full Genomes Products & Features

One of this company’s biggest draws is that it offers high-quality whole genome sequencing. This company offers several different tiers of its whole genome sequencing service, which are largely determined by the ‘coverage’ or read length. Coverage, in this context, refers to how accurate the sequencing results are. For example, 20x coverage will produce more accurate results than 10x coverage.

Whole Genome Analysis

If you have already had your DNA sequenced, you can upload your raw data to get it analyzed. Full Genomes offers the following tests:

• Whole Genome Sequence 15x, 20x, or 30x coverage: This is described as “next-generation” sequencing coverage.
• Long Read Whole Chromosome: The company’s most comprehensive genetic test uses linked-reads to facilitate the discovery of large structural rearrangements in the genome.

Y chromosome sequencing and analysis

The sequencing of the Y chromosome is available for males who want to reconstruct their paternal phylogenetic tree.

• Analysis of Y BAM files: If you already have a Y BAM file, you can upload it to analyze your paternal ancestry.
• Y Elite Ancestry Test for Men: This is a Y chromosome sequencing service. With this package, you can connect to other people around the world who share your paternal lineage.

Additional services

In addition to the services described above, the company offers several other services for those people who already have their DNA sequence information.

• Single nucleotide polymorphisms (SNP) Test: This service is for individuals who just want to upload their genetic data to look for a single, specific genetic variant at the single base pair difference level.
• Whole Genome GRCh38 Alignment: If you have a FASTQ file or a GRCh37 BAM file, this service can generate the latest GRCh38 version.
• Forensic SNP Imputation: This service allows you to upload your genetic data to compare it against the Full Genomes database to determine if you have any relatives within the database.
• Exome Sequencing: The exome (about 1% of your genome) refers to the pieces of your DNA that code for proteins. This is where most disease-related mutations are thought to occur.

Review of Full Genomes Reports

Several weeks after you return your samples to the lab, you will receive an email invitation to set up an account with FullGenomes. You will need an account to view your results. As is the case with many DNA analysis services, wait time for results can vary.

There have been cases when results have been delayed due to the lab seeking a more comprehensive analysis. Interpretation results will be available for download once you have received the email and logged into your account. The ‘Interpretation Results’ contain several files and instructions.

The results require more work and understanding of the consumer end than many other DNA testing companies. To make sense of the files provided, you will need to use an additional third-party software such as Promethease. You can read a full Promethease review here.

The files are categorized as Sequencing lab analysis and Full Genomes Analysis. The Sequencing lab analysis files contain the raw data that is generated by the Y chromosome sequence. There are four types of genetic variants included. There are instructions for understanding each variety included in the results. Even with an explanation, the process is quite complicated.

Full Genomes also includes a Genomes Analysis file. The Full Genomes analysis folder contains two files that you can easily open in Excel. The folders are called variantCompare and haploCompare.

The report identifies some high-reliability ‘private variants.’ With this report, you can compare the results to other registered Full Genomes accounts and identify recent mutations that may be shared.

Take note that these reports contain thousands of rows, and it can be challenging to obtain any meaningful information from them.

An S4744+ paternal haplogroup designation in the haplogroupCompare report

Full Genomes’ reports list the genetic variants that are understood to either be positive, negative, or interesting. They explain what each of these implicates in terms of physical appearance and health. The company also includes the likelihood of factors such as going bald or risk for heart disease.

This report is immensely helpful, especially if the customer has health concerns. If you want more thorough advice, you could resend this as a detailed DNA report to a medical professional of your choosing for further analysis.

A sample paternal haplogroup in the ISOGG tree from http://www.isogg.org

Cost of Full Genomes

The Full Genomes service is much more expensive than other commercial DNA testing products. The company has an extensive library of Y-chromosome SNPs, which allows you to explore your patrilineal background. This service is only available for men because women do not have a Y-chromosome.

Depending on the level of the test you would like to receive, Full Genomes is a significant investment. You can, however, get a single SNP test for only $15.

Whole Genome Sequencing (WGS) and Analysis

• Whole Genome Analysis – $75
• Whole Genome Sequence (coverages)
  • 15x – $645
  • 20x – $825
  • 30x – $1150
• Long Read Whole Chromosome – $2900

Y chromosome sequencing and analysis

• Analysis of Y BAM files – $50
• Y Elite Ancestry Test for Men – $425

Additional services

• Single nucleotide polymorphisms (SNP) Test – $15
• Whole Genome GRCh38 Alignment – $75
• Forensic SNP Imputation – $100
• Exome Sequencing – $525

SNP Analysis vs PRS vs Advanced PRS

Genetic testing can vary widely in what it reveals about your health, depending on whether it focuses on individual SNPs, basic polygenic risk scores (PRS), or advanced PRS. Single nucleotide polymorphism (SNP) analysis examines individual genetic variants, small changes in your DNA that may slightly increase or decrease your risk for certain traits or conditions.

Most consumer DNA tests rely heavily on this approach, which is inexpensive and relatively simple to understand, but limited in scope. Each SNP typically contributes only a tiny fraction to the overall risk of complex diseases, so evaluating a handful of variants provides a very narrow perspective, like reading a single sentence to understand an entire book.

Polygenic risk scores improve on this by combining the effects of multiple SNPs into a single score, capturing more of the polygenic nature of disease. Basic PRS models, however, often incorporate only a few dozen or hundred variants, which provides a better estimate of risk than single SNPs but still falls short of fully representing the complexity of human genetics.

Advanced PRS models, such as those offered by SelfDecode, analyze thousands to millions of variants and integrate additional clinical and demographic factors like age, sex, and ancestry. This approach produces the most accurate and reliable assessment of genetic risk, offering actionable insights that can guide personalized prevention, lifestyle changes, and medical decisions. While developing advanced PRS requires sophisticated algorithms, large datasets, and specialized expertise, the result is a far more meaningful understanding of your genetic profile compared to standard SNP testing or basic PRS.

Platforms like SelfDecode bring advanced PRS to consumers, translating this complex genetic information into practical recommendations, while tools like PromicsEdge and OmicsEdge provide professionals and health-tech companies with clinical-grade predictive capabilities. Ultimately, SNP analysis may offer an interesting glimpse into your DNA, basic PRS gives a broader view, but advanced PRS delivers the clearest and most actionable insights for understanding and managing your health.

Health Recommendations from Full Genomes

Full Genomes is strictly a DNA sequencing service and does not include any recommendations in their reports, despite offering limited health information. You will need to take your DNA data to your own specialist who can then interpret your genes to give you any health recommendations.

Review of Full Genomes Privacy & Data Security

According to Full Genomes Terms of Service, the customer has the right to request that their account be closed and their information removed from all databases.

Unless the customer requests otherwise, or the law prevents it, DNA samples are destroyed after the laboratory finishes the analysis. Any customer has the right to “opt-in” or “opt-out” of uses of personal information. This process is complicated, and to do so, you must message the privacy administrator.

Full Genomes Reviews

The editor at bestdnatestingkits gave Full Genomes 4/5 stars, calling it “worth a substantial investment”. They highlight the detailed report information and extensive database as justification for the higher cost compared to other services.

Customer reviews on dnatestingchoice gave it an average 4.5/5 star rating, from 32 reviews. Many reviewers praised the customer service and were impressed by the information given versus the lack of fancy graphical reports.

Alternatives to Full Genomes

For individuals seeking more than raw DNA sequencing and limited health information, SelfDecode offers a compelling alternative.

Unlike Full Genomes, which focuses primarily on whole genome sequencing and Y-chromosome analysis, SelfDecode delivers actionable, science-backed insights by integrating advanced ancestry-adjusted polygenic risk scores, symptom analysis, and multiomics data.

The platform analyzes millions of variants per report, providing personalized recommendations for diet, supplements, lifestyle, and disease prevention. SelfDecode’s approach is validated in multiple peer-reviewed studies published in top-tier journals, making it one of the most reliable consumer genetics platforms available.

Additionally, it integrates blood test results alongside genetic data, enabling a truly multiomics perspective on health. Privacy and security are prioritized, with full HIPAA and GDPR compliance, giving users confidence that their sensitive information is fully protected. While developing SelfDecode’s advanced algorithms required significant investment, its comprehensive reports and actionable recommendations offer a level of usability and precision that raw sequencing services alone cannot match.

While Full Genomes excels at providing raw genetic data and detailed Y-chromosome analysis for ancestry enthusiasts, SelfDecode goes further by translating genetic and clinical data into meaningful, evidence-based recommendations.

Users gain insights they can act on immediately, whether it’s adjusting their diet, optimizing supplementation, or monitoring health risks with advanced polygenic risk scores. For anyone looking to take control of their health rather than simply explore their genome, SelfDecode provides a more practical and scientifically validated solution.

Full Genomes Review Summary

Full Genomes is for anyone interested in a thorough explanation of their DNA. With a variety of levels and prices of products available, there is something for everyone.

This test is definitely not for the faint-hearted. There’s a very steep learning curve and once you start, there’s a mountain of research you can read through, dozens of projects to join, and dozens of additional analyses you can undertake. You’re not going to get any user-friendly reports, but if you’re detail-orientated, researching your paternal ancestry can be very compelling.

Full Genomes offers limited health information, but no recommendations. An alternative such as SelfDecode provides you a more affordable option with science-backed and easy to understand reports in addition to a personalized health blog to help you take control of your health.

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