Muhdo Review: Can a DNA Test Help Your Fitness Goals?

Overview

1. Products: At-home DNA and epigenetic test kits focused on wellness, fitness, and lifestyle insights.
2. Cost: Individual test kits typically range from £250–£375, with optional supplements sold separately.
3. Reports: Diet, fitness, and health reports.
4. Raw data access: Does not clearly offer downloadable raw genetic data.
5. Privacy: Muhdo claims not to release identifiable personal information to third parties.
6. Alternatives: SelfDecode offers more advanced genetic analysis, deeper health reporting, and Polygenic Risk Scores (PRS).

Pros

• At-home DNA and epigenetic testing
• Includes an AI health coach experience
• Offers worldwide shipping

Cons

• Does not offer Polygenic Risk Scores (PRS)
• Analyzes a limited number of SNPs compared to more advanced genetic platforms
• No ability to upload or track external lab results
• Strong emphasis on selling supplements alongside health data
• Does not publicly state HIPAA compliance
• Covers a limited number of health topics compared to broader genetic health platforms

About Muhdo

Muhdo is a UK-based health technology company founded in 2016 and headquartered in Ipswich, Suffolk. The company was founded by Nathan Berkley (CEO) and James Brown and focuses on DNA and epigenetic testing for wellness, aging, and lifestyle optimization.

Review of Muhdo Products & Features

Muhdo’s product lineup is centered around at-home testing kits and a digital dashboard experience. The main offerings are three core kits: a DNA Kit, an Epigenetic Kit, and a combined DNA + Epigenetic Kit. Each of these kits can be purchased on their own or bundled with access to an “AI Health Coach” feature.

While the AI Health Coach is positioned as a personalized guidance tool, there is limited publicly available information about how the system works, what data it is trained on, or how its recommendations are validated. This makes it difficult for consumers to independently evaluate the accuracy, scientific grounding, or clinical reliability of the guidance provided.

Similarly, Muhdo offers limited technical transparency around how its DNA and epigenetic tests are processed, analyzed, or interpreted. There is little published information about laboratory partners, testing standards, or analytical methods, which makes it hard to assess the scientific rigor behind the results.

Beyond testing kits, Muhdo also sells supplements and branded wellness products through its online shop. While this creates an “all-in-one” ecosystem, it also introduces a strong commercial layer that can blur the line between data-driven insights and product-based recommendations.

Muhdo currently offers an epigenetic test as part of its platform, but it does not provide access to additional clinical lab testing, nor does it allow users to upload and track their own external lab results. This limits its usefulness for people who want a more complete, centralized view of their long-term health data.

Review of Muhdo DNA Test

Muhdo’s DNA test is sold as a single at-home saliva kit that focuses on lifestyle and wellness insights rather than clinical-grade health data. According to the company, the test covers “over 187 health areas”, mostly grouped into broad categories such as nutrition, stress, exercise, aging, and supplementation.

While 1,000 markers may sound substantial, Muhdo does not clearly publish a detailed list of the specific SNPs tested, nor does it provide transparent documentation about how those markers are selected, weighted, or validated. This makes it difficult for users to independently evaluate the scientific depth or clinical relevance of the analysis.

Another limitation is the lack of polygenic risk scoring (PRS). Muhdo’s DNA test does not appear to calculate multi-gene risk scores for complex conditions such as cardiovascular disease, diabetes, neurological disorders, or cancer risk, which are increasingly considered a standard feature in more advanced genetic analysis tools.

Muhdo also provides very little publicly available information about its laboratory methods, genotyping platforms, or data processing pipelines, which makes independent evaluation of accuracy and reliability difficult.

Overall, Muhdo’s DNA test appears geared toward general lifestyle optimization rather than detailed, research-level genetic analysis.

SNP Analysis vs PRS vs Advanced PRS

Many consumer DNA companies still rely on single-SNP analysis, while more sophisticated platforms use Polygenic Risk Scores (PRS) or advanced PRS models. The difference between these approaches has a major impact on how accurate and useful the results actually are.

Single-SNP analysis looks at a small number of individual genetic variants and reports whether someone has a “higher” or “lower” tendency for certain traits. The problem is that most individual SNPs contribute less than 1% to the risk of complex diseases.

Looking at only a handful of variants gives a very limited picture, similar to trying to understand an entire book by reading a single sentence. This approach is common because it is cheap and easy to build, but it offers weak predictive power.

Basic Polygenic Risk Scores improve on this by combining the effects of hundreds or thousands of genetic variants into a single risk score. Instead of focusing on one gene at a time, PRS models look at patterns across many genes at once.

This better reflects how real diseases work, because most health conditions are influenced by large numbers of small genetic effects working together. As a result, PRS tends to provide more reliable and more actionable insights than single-SNP testing.

Advanced PRS models go further by analyzing thousands to millions of genetic variants, often alongside non-genetic factors such as age, sex, ancestry, and other clinical indicators.

Platforms such as SelfDecode, powered by OmicsEdge, have brought these advanced PRS models directly to consumers. These platforms integrate large-scale genetic analysis with validated statistical methods and clinical context, producing more reliable and meaningful risk assessments than traditional single-SNP or limited PRS approaches.

In practical terms, this means that platforms relying on only a few SNPs tend to provide simplified genetic snapshots, while advanced PRS systems, like those developed by OmicsEdge and used by SelfDecode, provide a much clearer and scientifically reliable view of genetic risk.

Understanding which methodology a company uses is essential when evaluating whether a genetic testing service is offering meaningful health insights or just surface-level genetic information.

Cost of Muhdo

Users choose which type of biological testing they want and can add supplements separately if needed.

• DNA Kit + AI Health Coach: £250
• Epigenetic Kit + AI Health Coach: £250
• DNA + Epigenetic Kit + AI Health Coach: £375

In addition to testing, Muhdo sells branded supplements. These typically range from £20 to £78 per product, depending on the specific formula.

Review of Muhdo Privacy & Data Security

Muhdo states that customer genetic data is anonymized using unique IDs, encrypted during storage and transfer, and hosted on secure AWS servers. The company also claims compliance with EU GDPR regulations.

However, Muhdo provides limited technical detail about its security architecture, encryption standards, or independent audits. It also does not publicly state that it is HIPAA compliant, which may be a concern for users in the United States.

Alternatives to Muhdo

Several platforms offer more advanced or specialized genetic and precision health tools, depending on the type of user.

SelfDecode is a strong alternative for direct-to-consumer users. It focuses on deeper genetic analysis, advanced Polygenic Risk Scores (PRS), and highly detailed health reports. Unlike platforms that rely mostly on trait-level scoring, SelfDecode offers broader condition-level insights, lab integration, and personalized recommendations based on genetics, lifestyle, labs, and symptoms.

PromicsEdge is designed specifically for healthcare professionals and clinics. It provides practitioners with advanced genomics tools, PRS-based risk models, and clinical-grade reporting systems that can be integrated into professional workflows. This makes it more suitable for medical, functional medicine, and research-oriented environments.

For health-tech companies and businesses, OmicsEdge provides enterprise-level genetic and precision health infrastructure. It supplies advanced PRS models, genetic risk engines, and integration tools that allow companies to build their own products and platforms. The difference is that OmicsEdge is more focused on scalable, research-driven risk modeling and enterprise integrations.

Compared to Muhdo’s consumer-focused and lifestyle-oriented ecosystem, these alternatives tend to offer more depth, scalability, and scientific transparency depending on the user’s needs.

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Muhdo Review Summary

Muhdo presents itself as a preventative health platform focused on DNA and epigenetic testing, with an emphasis on lifestyle and wellness optimization. Its at-home testing kits and clean digital experience make it accessible to users who are new to genetic-based health tools.

However, a major limitation of the platform is its genetic analysis depth. Muhdo does not provide advanced Polygenic Risk Scores (PRS), which are increasingly considered the standard for evaluating genetic risk in complex diseases. Instead, it relies on simplified trait-based scoring models.

Although the company states it analyzes around 1,000 genetic markers, it does not publish a full list of SNPs tested or clearly explain how those markers are weighted and validated. This lack of transparency makes it difficult to independently assess the scientific robustness of the results.

Overall, Muhdo may be suitable for general wellness insights, but its lack of advanced PRS, limited genomic transparency, and simplified genetic modeling make it less compelling for users seeking detailed, clinically relevant genetic risk analysis.

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