Endo·dna Review: Custom CBD Products Based on Your DNA?

Overview

1. Products: Endo·dna Collection Kit and Endo·Decoded Report, Free Immune Function Genetics Report
2. Cost:
   • Endo·dna Collection Kit and Endo·Decoded Report: $199
   • Endo·Decoded Report Upload License: $49.95
3. Reports: Endo·Decoded Report, Immune Function Genetics Report
4. Raw data access: Yes, upon request
5. Privacy: Does not share or sell your personal information
6. Alternatives: SelfDecode: The best option for health-focused DNA analysis with personalized reports, symptom analysis, and health recommendations.

Pros

• Trait reports for endocannabinoid system-related health topics
• Allows you to upload your raw DNA data

Cons

• Endo·dna does not sell most of the cannabis formulations themselves, but rather links you to a 3rd party cannabis product manufacturer
• The Endo·dna test only analyzes SNPs related to your endocannabinoid system.
• It does not offer information or health recommendations other than those specific to traits associated with your endocannabinoid system
• Does not offer advanced polygenic risk scoring.
• Does not integrate lab analysis to provide health insights.

About Endo·dna

Endo·dna is the latest version of the DNA testing product of EndoCanna Health, which was founded in 2017 by Len May and Eric Kaufman.

Like many people in their early teens, Len May was diagnosed with Attention Deficit Disorder. As a result, he was put on a number of drugs only to discover that cannabis was the best treatment for his condition. His mission became to educate as many people as possible on the benefits of cannabis, and he became the president of the Cannabis Action Network – an organization to fight for the legalization of cannabis.

On July 29, 2019, EndoCanna Health received $1.52M in seed funding from Heritage Cannabis Holdings based in Vancouver, Canada. EndoCanna Health has also partnered with New Coastal Group, Inc. (a CBD product manufacturer) to power their DNA test kit.

Review of Endo·dna Products & Features

The Endo·dna test looks at SNPs related to your endocannabinoid system. An Endo·dna test may be able to tell you:

• THC tolerance
• The genetic expression, or effect, individual terpenes may have on your endocannabinoid system.
• Your metabolic function level which can help determine how you should use cannabis or CBD products, and the amount you should take.
• Any drug-to-drug interactions you could experience.

The Endo·Decoded Report Upload License supports files from the following 3rd party providers:

• 23andMe© V3, V4, V5
• AncestryDNA™ V1, V2
• Diagnomics
• MyHeritage™
• SoWello
• Terrain10

The newest product is the free Immune Function Genetics Report, which is comprised of:

• 8 immune function trait reports.
• 3 vitamin deficiency predisposition reports.
• Next steps to address risk factors and cautions.
• Mydna.live account.
• Resources and tools to help support your immune health.

Review of Endo·dna Reports

The Endo·Decoded Report can help you in choosing the right cannabis product. This report can be accessed via the MyDNA.live online portal.

Once you have uploaded your compatible DNA file, or registered your kit and have it analyzed, the MyDNA.live site will display your dashboard with twelve report categories to choose from. You can also access your Wellness Plan to help you choose the products.

Each Report category lists several Trait Reports, and each of them indicate your level of risk. Clicking the Risk Indicated hyperlink takes you directly to the specific Trait Report.

The Trait Report section tells you the genes that were assessed, and the markers used to determine your risk factors. More information on each gene analyzed also can be viewed in this section.

Inside the summary of findings, you will see any relevant genotype that you have in the category. Following that is a quick summary of the research as it relates to your genetic predisposition in this specific category.

Next, there is an assessment of your risk based on that research and your genotype. Your recommended CBD to THC ratios and your terpene profile can also be seen in this section.

In the Scientific Findings & Your Results section, a summary of all the relevant studies used in the assessment of your genetic markers is provided. The specific genes, markers and your genotype are also displayed. The “Your Results” section details the specifics of your risk factors and an interpretation of the findings. Finally, there is a popup window that provides information to compare your specific gene, marker and genotype with other populations.

Each Trait Report provides a Frequently Asked Questions section related specifically to the topic. At the bottom of each Trait Report, you’ll find a link to your Wellness Plan, where you can access the specifics about the Endo·Aligned formulation suggestions.

Specific Endo·Aligned Formulations may be suggested for several conditions. The Wellness Plan provides recommendations for Endo·Aligned Formulations, but does not suggest other lifestyle changes you can easily implement to address your genetic predisposition to the traits analyzed.

Immune Functions Genetic Test

While there is currently no test to determine someone’s actual susceptibility to COVID-19, Endocanna Health offers a free report on genetic factors that impact immune health. This test claims to be able to tell you:

• Your genetic predisposition to more severe symptoms of acute respiratory tract infections.
• Potential risk of developing severe influenza symptoms.
• Your genetic predisposition to stress.
• Your predisposition to specific autoimmune irregularities which could impact your body’s response to viruses.
• Your genetic predisposition to experiencing intense emotional reactions in response to stress.
• Information, resources and tools to support a proactive immune health and wellness plan for you and your family.

Cost of Endo·dna

The Endo·dna Collection Kit and Endo·Decoded Report costs $199. An upload license for raw genetic data files from other popular DNA testing sites costs $49.95. The products that are recommended cost anywhere from $25 to $135. The Immune Functions Genetic Test is free, but you need to already have a raw DNA file from Endo·dna or another compatible provider.

Health Recommendations from Endo·dna

The Endo·dna reports only tell you what your risks are for certain traits, and then direct you towards commercial CBD products that may address those risks. They do not offer lifestyle, diet, exercise, or other health recommendations to help you address your genetic predisposition to the traits analyzed.

SNP Analysis vs PRS vs Advanced PRS

When it comes to understanding genetic risk, not all analyses are created equal. The difference between SNP analysis, polygenic risk scoring (PRS), and advanced PRS lies in how deeply each method interprets your DNA to provide meaningful insights into your health.

Most companies, including Endo·dna, rely on basic SNP analysis, which examines single genetic variants in isolation. While this can identify certain traits or single-gene conditions, it fails to capture the complex interactions between thousands, or even millions, of variants that contribute to most common health conditions.

PRS (Polygenic Risk Scoring) takes a major step forward by evaluating the combined effect of many variants across the genome. This provides a more accurate estimation of risk for multifactorial conditions such as heart disease, diabetes, or depression. However, most companies offering PRS still rely on generalized models that do not account for ancestry or other biological variables, which can lead to biased or less precise results.

SelfDecode’s Advanced PRS, on the other hand, represents the most sophisticated approach currently available. Using ancestry-adjusted PRS models published in a Nature journal, SelfDecode integrates over 200 million variants through AI-powered algorithms that deliver the most accurate predictions in the industry.

These models are validated by six published studies in top-tier journals and further refined using additional health data such as lab results, symptoms, and lifestyle factors.

This integration, known as Multiomics, allows SelfDecode to connect genetics with real-world biological data, offering personalized diet, supplement, and lifestyle recommendations that are scientifically validated and uniquely tailored to each user.

In contrast, companies like Endo·dna remain limited to surface-level SNP insights focused only on the endocannabinoid system. For those seeking a complete picture of their health, SelfDecode’s advanced PRS and Multiomics platform offer the accuracy, validation, and personalized guidance that basic SNP analysis simply cannot match.

• Read more: Why Advanced Polygenic Risk Scores Outperform Significant SNP Analysis

Review of Endo·dna Privacy & Data Security

Endo·dna de-identifies your DNA data, and the only identifier to you or your information is an anonymous and randomly generated barcode which does not contain any personal information about you. Endo·dna abides by HIPAA regulations and guidelines for data privacy and security to safeguard medical information.

When you register your barcode on mydna.live, your DNA results are anonymously matched with your registration information. Endo·dna does not share or sell your personal information, and you may request the deletion of your account and information at any time. They do not store or archive your DNA sample for any longer than necessary to provide your results.

Endo·dna in the News

Endo·dna has several appearances in articles and podcasts across the web. Len May has appeared in podcasts on headsuphealth.com and cannabistech.com, where he talks about the benefits of matching commercial CBD formulations to your personal genetic profile.

They were reviewed by Meg Hartley on leafy.com, and she gave the service a positive recommendation.

Alternatives to Endo·dna

While Endo·dna focuses on SNPs related to the endocannabinoid system and provides cannabis-related insights, its scope is limited compared to a full-scale precision health platform like SelfDecode. For those who want to understand their overall health—not just how they respond to CBD—SelfDecode delivers the most comprehensive, science-backed solution in the industry.

Unlike Endo·dna’s narrow focus, SelfDecode uses advanced ancestry-adjusted Polygenic Risk Scoring (PRS) published in a Nature journal, analyzing over 200 million variants to provide the most accurate predictions for hundreds of health traits and conditions. Each prediction is supported by six published validation studies in top-tier scientific journals, ensuring both reliability and accuracy.

Beyond DNA, SelfDecode integrates Multiomics data, combining genetic insights with blood test results, symptoms, and environmental factors using AI-driven analysis. This allows for personalized recommendations that include diet, lifestyle, and supplement suggestions, something Endo·dna and similar companies simply don’t offer.

SelfDecode also upholds strict privacy standards, complying with HIPAA and GDPR, and offers 1,500+ health reports across multiple categories, each designed to help users take informed and actionable steps toward better health. With more than $25 million invested in development, SelfDecode’s platform stands at a level of depth, accuracy, and scientific rigor unmatched by low-cost SNP-based tools.

Endo·dna Review Summary

If you are looking for an effective commercial CBD product to help you deal with specific health issues, then getting your DNA analyzed by Endo·dna might point you in the right direction.

However, you won’t get any other health insights or recommendations outside those related to your endocannabinoid system. The results can help you choose the right CBD products but won’t offer recommendations to help you address your genetic predispositions to the traits included in the reports.

If you’re looking to optimize your overall health, you’ll need much more than an analysis of SNPs related to your endocannabinoid system. An alternative such as SelfDecode provides you a more comprehensive option with science-backed and holistic health reports and recommendations in addition to their personalized health blog to help you take control of your health. SelfDecode is the only DNA company that uses AI and machine learning to analyze up to 200 million genetic variants to give you the most accurate results.

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